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JCI,  · In the rd10 mouse model of RP, oral administration of NAC promoted prolonged cone survival and maintenance of cone electroretinographic function (). Herein, we report a dose-ranging study to assess the safety, tolerability, and effects of NAC treatment on multiple parameters of visual function in patients with RP.,  · From [email protected] Sat Dec 02 13:30:05 2006 Received: from [] (helo=) by with esmtp (Exim ) id 1GqZcj-0007KG-CU for [email protected]; Sat, 02 Dec 2006 13:30:05 -0500 Received: from [ ...JCI,  · We favor a model in which this signaling induces microglia to create a retinal environment favorable to cone survival. Our findings thus highlight a new immunomodulatory strategy centered around microglia for treating patients with RP, an approach that may also be relevant for other degenerative diseases of the visual system and CNS.

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